January 23, 2015
The International Rare Cancers Initiative (IRCI) is a partnership which aims to stimulate and facilitate the development of international clinical trials for patients with rare cancers. The European Journal of Cancer published methods used in the IRCI portfolio. Clinical trials can be designed based on different methodologies to adapt to challenges faced when studying rare cancers. The article describes novel approaches to conducting clinical trials for rare cancers, in the context of restricted sample sizes and lack of natural history data. The article recognizes the benefits of unconventional methods to conduct clinical trials.