Academy of Finland

2015

  • Beta carbonic anhydrase: a new silver bullet against parasitic diseases
  • Defects of early differentiation of patient-specific neural progenitors in autism spectrum disorder
  • Molecular Mechanisms of Thyroid Disorders: from Human Diseases to Mouse Models
  • Muscular dystrophy : molecular pathophysiology of titin mutations and translational medicine
  • Nuclear Lamin A in Dilated Cardiomyopathy
  • The role of polyamine metabolism and NAD+-dependent enzymes, sirtuins and poly(ADP-ribose) polymerases, in diseases characterized with mitochondrial dysfunction.

2014

  • Clinical and genetic characteristics of early-onset osteoporosis
  • Maternal and fetal genetic susceptibility to pre-eclampsia
  • Reprogramming normal cells to tissue-specific cancer by defined oncogenic factors
  • Role of Novel Neurotrophic factors CDNF and MANF in genetic models of amyotrophic lateral sclerosis
  • The pathogenesis of childhood acute leukemia
  • Vasculopathy in hantavirus infections

2013

  • Correlation between alterations of neural stem cell differentiation and phenotype in fragile X syndrome, a model of neurodevelopmental disorders.
  • Maintenance and translation of mitochondrial DNA in severe multiorgan disorders of childhood.
  • Nutrient signaling in mitochondrial diseases: molecular mechanisms and strategies for therapy.
  • Screening the Drosophila genome for new genes involved in mtDNA maintenance and metabolism.

2012

  • Identifying New Therapeutic Targets For Hereditary Breast Cancers
  • “NARPANord” – Pathogenesis of Narcolepsy. Narcolepsy as an autoimmune disease and its association with H1N1 epidemics, H1N1 vaccination and other potential environmental triggers-A collaborative Finnish-Swedish project
  • Apoptosis-induced microparticles and apoptotic bodies as stimuli to plasmacytoid dendritic cell-mediated autoimmunity vs. Tolerance: regulation by estrogens and androgens in an autoimmune exocrinopathy
  • Craniosynostosis: identifying the mechanisms and preventing the disease
  • Individualized and combinatorial therapy of AML
  • Lipid-protein interactions in the mitochondrial inner membrane at nucleoid contact sites
  • Modelling of monogenic diabetes through stem cells
  • Molecular mechanisms of neurodegeneration caused by mitochondrial disfunction
  • Regulation and signaling networks of different Akt isoforms in glioblastoma
  • Tissue specificity of mitochondrial DNA maintenance
  • Translational studies of GRACILE syndrome – a model disorder for revealing disease mechanisms and intervention efficacy in mitochondrial dysfunction

2011

  • Fanconi Anemia/BRCA Pathway and Novel Predisposing Factors in Hereditary breast cancer
  • Functional and clinical significance of MED29 and ARPC1A amplification target genes in pancreatic cancer
  • Identification of genetic factors predisposing to diabetic nephropathy
  • Identify underlying mechanisms connecting autosomal dominant and recessive mitochondrial disease mutations to tissue specific phenotypes
  • Idiopathic pulmonary fibrosis (IPF) -Development of therapeutic applications
  • Mechanisms and consequences of mitochondrial translation defects
  • Mitochondria, metabolism and disease
  • Mouse and cellular models expressing the alternative oxidase: tools to understand and compensate mitochondrial dysfunctions
  • Strategies to modify mitochondrial function in order to delay damage generation, increase healthy lifespan and prevent age-related diseases

2010

  • Alphavirus-induced oncolysis of glioma in immune competent mice: development of sensitive biokmarkers and their use in immunosuppressive combination therapies
  • Canine Models Of Human Idiopathic Epilepsy
  • Complex genetics of idiopathic epilepsies
  • Fetal and childhood mitochondrial genetics and function-effects of novel genes, antiepileptic drugs and alcohol exposure
  • Finnish Centre of Excellence in Research on Mitochondrial Disease and Ageing (FinMIT)
  • Identification of genetic factors predisposing to diabetic nephropathy
  • Identifying New Therapeutic Targets For Hereditary Breast Cancers
  • Idiopathic pulmonary fibrosis (IPF) -Development of therapeutic applications
  • iPS cells as tools to study mitochondral disorders
  • Microglial dysfunction in progressive myoclonus epilepsy, EPM1
  • Migraine-epilepsy co-morbidity: Rare variants as a tool for identification of susceptibility genes
  • Mitochondria, metabolism and disease
  • Mouse and cellular models expressing the alternative oxidase: tools to understand and compensate mitochondrial dysfunctions
  • Muscular dystrophy — molecular pathophysiology of titin mutations and translational medicine
  • Nuclear-mitochondrial interactions in Drosophila models of human disease
  • Role of Kaposi sarcoma herpesvirus-induced cellular reprogramming in cancer development