National Eye Institute (NIH), USA

2015

  • Biocompatible retinal prosthesis based on a conjugated polymer photoactive layer
  • Biomechanical analysis of the cornea and keratoconus
  • Cone opsin in photoreceptor degeneration
  • Cytomegalovirus retinitis pathogenesis: mechanisms of retinal tissue destruction
  • Disease mechanisms in best disease
  • Disease models for high throughput screens
  • Drug discovery and mechanistic study of p23h rhodopsin associated retinitis pigmentosa
  • Gene silencing and gene editing in phototransduction
  • Human connectomes for low vision, blindness, and sight restoration
  • Ire1 alpha inhibitors for retinal degenerative diseases
  • Manufacturing pathogen inactivated platelet lysate to treat corneal inflammation
  • Molecular therapies for lebers congenital amaurosis caused by kcnj13 mutations
  • Mouse model for eyelid disease: congenital blepharophimosis
  • Regulation of eye morphogenesis
  • Retinitis pigmentosa therapy with human embryonic stem cell- and induced pluripotent stem cell-derived photoreceptor progenitors
  • Secondary analysis of the data from the telemedicine approaches to evaluating acute-phase rop (e-rop)
  • The molecular basis of liver induced retinal blood vessel plasticity.
  • The role of complement in recessive stargardt disease
  • The role of plasmacytoid dendritic cells in corneal immunity
  • The role of transcription factor 4 repeat expansion in fuchs endothelial corneal dystrophy
  • Wavefront guided customized soft contact lens for highly aberrated eyes

2014

  • A high content screening approach for the retinal degenerative diseases
  • Ataxin-7 oligonucleotide knock-down to treat sca7 retinal and cerebellar disease (website)
  • Choroidal blood flow imaging with spectral domain oct (website)
  • Developing efficient aav vectors for photoreceptor targeting via the vitreous (website)
  • Development of redox-active therapies for ischemic optic neuropathy
  • Dhdds and retinal degeneration (website)
  • Directed evolution of adeno-associated virus for retinal gene therapy (website)
  • Evaluating a non-contact fundus camera for retinopathy of prematurity screening (website)
  • Fiber cell membrane organization-role in lens architecture and function
  • Fully automatic rop screening system: neoscan (website)
  • Immune mechanisms in ocular graft versus host disease (website)
  • Modeling photoreceptor development and disease using human pluripotent stem cells (website)
  • Nanoparticle-mediated gene delivery for rhodopsin-associated retinitis pigmentosa (website)
  • Non-linear optical collagen cross-linking (nlo cxl) for treatment of keratoconus (website)
  • Phage display selection of antiangiogenic cmg2 cyclic peptide antagonists
  • Physiologically based markers of idiopathic intracranial hypertension (website)
  • Preclinical preparation for the boston retinal implant device
  • Prevention of retinal degeneration by transgenic autologous stem cells (website)
  • Programmed cell death in anterior eye development and peters’ anomaly (website)
  • Quantitative fundus autofluorescence in retinal disorders (website)
  • Rhodopsin-mediated phospholipid flipping (website)
  • Role of optical aberrations in 3d space perception: implications for keratoconus (website)
  • Suppressing thyroid hormone signaling to protect cones in retinal degeneration (website)
  • Transcriptional regulation of retinal mitochondrial function and cell cycle

2013

  • 3D Image Analysis Approach to Determine Severity and Cause of Optic Nerve Edema (website)
  • A Drosophila Model for Charcot-Marie-Tooth 2B Disease (website)
  • Automated retinopathy of prematurity classification using machine learning (website)
  • Circulating Immune Biomarkers and Retinopathy of Prematurity (website)
  • Coherent light scattering for early detection of retinal disease (website)
  • Compacted DNA Nanoparticles for Ocular Therapy (website)
  • Cyclodextrins as potential treatment for age related macular degeneration (website)
  • Delaying Cone Death in Retinitis Pigmentosa (website)
  • Documentation of Novel Keratoconus Markers: In Vitro and In Vivo (website)
  • EYA in Retinal Angiogenesis (website)
  • Gene Discovery in Familial Keratoconus (website)
  • Gene therapy to support cone metabolism in retinitis pigmentosa (website)
  • Investigation of nuclear transport dysfunction in an ocular model of FTLD (website)
  • Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis Pigmentosa (website)
  • Processing Streams In Mouse Visual Cortex (website)
  • RETIVUE WF – A handheld, high-resolution, wide-field retinal imager
  • Role of impaired protein degradation in photoreceptor degeneration (website)
  • Role of Optineurin in Ocular Herpes Infection (website)
  • The role of plasmacytoid dendritic cells in corneal immunity (website)
  • Unfolded Protein Response as a Therapeutic Target for ADRP Animal Models (website)

2012

  • Adaptive optics scanning laser ophthalmoscope-based microperimetry: establishing (website)
  • Bcl-2 and ocular neovascularization (website)
  • Cone opsins in photoreceptor degeneration (website)
  • Cortical Areas and Neural Connections Underlying Scene Processing (website)
  • Defining the neural correlates of ensemble representation (website)
  • Function of ciliary disease protein Retinitis Pigmentosa GTPase Regulator (RPGR) (website)
  • HDAC4-mediated Photoreceptor Protection in Retinal Degeneration (website)
  • Large animal therapy studies (website)
  • LCA Gene Therapy in Somatic Cell-Derived Induced Pluripotent Stem Cells (website)
  • Molecular Basis of Human Visual System Disorders (website)
  • Molecular Pathophysiology of Retinal Degeneration in Bardet-Biedl Syndrome (website)
  • Neuroprotective agents for retinal diseases (website)
  • Optimization of an Optogenetic-Based Vision Therapy for Retinitis Pigmentosa (website)
  • Pathogenesis of Vaccinia virus keratitis (website)
  • Postnatal Growth and Retinopathy of Prematurity (G-ROP) Studies (website)
  • Regulation of Ocular Neural Crest and its Implications in Congenital Eye Diseases (website)
  • Regulation of the Hippo pathway and its role in uveal melanoma (website)
  • Role of Nrf2 in retinal vascularization and ROP (website)
  • Sigma-1 Chaperone-Mediated in vivo Neuroprotection in the Retina (website)
  • Structure & Function of Ganglion-Cell Photoreceptors Contributing to Form Vision (website)
  • The Role of Nephrocystin-5 in Retinal Degeneration (website)
  • Visual outcome measures in children with optic pathway gliomas (website)

 

2011

  • Carotinoids in Vision (website)
  • Completing genetic analysis of the ABCA4 locus  (website)
  • Cortical Structure and Function in Blindness and following Restored Vision (website)
  • Evaluation of stem cell-derived retinal pigment epithelial cells for retinal disease (website)
  • Formation and New Components of the Usher 2 Protein Complex in Photoreceptors (website)
  • Gene Expression in Nonspecific Orbital Inflammatory Disease (website)
  • Investigating the Role of Hypoxia Inducible Factors in Pathological Retinal Angio (website)
  • Longitudinal Neuroimaging of Leber’s Congenital Amaurosis After Gene Therapy (website)
  • Modifiers of Retinal Phenotypes in Ciliopathies (website)
  • Molecular Mechanisms of Human Retinal Disease (website)
  • Mouse model for eyelid disease: Congenital blepharophimosis (website)
  • Neuronal Cell Cycle and Survival (website)
  • New Approach to promote optic nerve regeneration and vision restoration (website)
  • Outcomes of children with juvenile idiopathic arthritis-associated uveitis (website)
  • Pax6, CtBP and the regulation of transcription in Drosophilia eye specification (website)
  • Prevention of Retinopathy of Prematurity with a Novel Bifunctional Redox Reagent (website)
  • Regulation of normal and Leber congenital amaurosis-associated RPE65s (website)
  • Serotonin Receptor Modulation of Neurotrophic Factors in the Retina (website)
  • Statisitical design, monitoring & coord. Of vision clinical trials & epidemiology (website)
  • The Pathogenesis of RNA Splicing Factor RP (website)
  • The role of microRNAs in the development and differentiation of mouse photorecept (website)
  • The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity (website)
  • Therapeutic approaches for ABCA4-associated disorders (website)
  • Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols (website)
  • Understanding uveitis in a multi-system disease model of spondyloarthropathy (website)
  • Zebrafish Model of Human Corneal Development and Disease (website)
  • Zonule Assembly and Ectopia Lentis (website)

2010

  • A New LCA Model By Polarity Gene Ablation (website)
  • Clinical and Genetic Analysis of Retinopathy of Prematurity (website)
  • Development of a non-rodent model using light-activated channel technology to cur (website)
  • Endogenous Specific Inhibitor of Corneal Lymphangiogenesis (website)
  • Endoplasmic Reticulum Stress in Retinal Degeneration (website)
  • Illuminating the process of rod outer segment morphogenesis (website)
  • In-vivo, High Contrast Imaging of the Human Rod Photoreceptor Mosaic (website)
  • P23H Rhodopsin Mutant Swine Model of Reninitis Pigmentosa (website)
  • Pharmacological Treatment of Retinal Diseases (website)
  • Quality control mechanisms against misfolded rhodopsins in Drosophila (website)
  • Rod Cone Interactions in Mesopic Vision (website)
  • Role of corneal neuropeptides in the pathogenesis of herpetic stromal keratitis (website)
  • Telemedicine Approaches to Evaluating Acute-phase ROP – eROP (website)
  • The Role of RNA Splicing Factors in Retinal Degeneration (website)
  • Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits (website)