Changes in gene patent laws have led to many questions among the organizations who want to patent next generation sequencing technologies. In a report published in Nature Biotechnology the current understanding of patent laws in this area of NGS industry leaders is expressed. They found that even the industry leaders were confused or troubled by four important points of patent law which are detailed in the report. There is confusion regarding innovations that can be patented. They misjudged the validity and enforceability of competitors’ and one’s own patents and when they can be enforced and the actions constituting patent infringement and penalties associated with it. The authors clarify these issues in this report and inform the readers on these topics.